The properties of metal nanoparticles are significantly affected by their size distribution and aspect ratio, as well as faceting of the crystallographic surfaces. The aim of this presentation is to gain insight into the inhomogeneous growth and dissolution of silver nanoparticles using real-time liquid transmission electron microscopy. The solution used to fill the liquid cell was prepared by dissolving silver nitrate (AgNO3) in deionized (D.I) water. The assembled custom-built liquid cell stage was loaded into the TEM (JEOL, JEM-2010F), which was operated at 200 kV. It was reported that the Scanning TEM (STEM) and CTEM modes provide different results in liquid TEM because of the difference in current density and illumination area of the electron beam. Parallel illumination in conventional TEM (CTEM) was used in this experiments. Small equiaxed silver nanocrystals were observed for the first 5 seconds with electron beam irradiation. Inhomogeneous, preferential growth was observed started from one corner of the frame after 35 seconds. Unlike the typical nano-particle growth, growth of the silver nanoparticles from seeds was anisotropic, with unidirectional growth. Subsequently, growth of nano-partlicles located at the center of the screen occurred after 55 seconds. In the same region of unidirectional growth, dissolution of nanoparticles were also observed. After 75 seconds of exposure, reactions of particle growth were occurred in the region of the unchanged. Finally, after 95 seconds, growth saturated, and silver nanoparticles covered the entire observation area. The interpretation of the inhomogeneous growth and dissolution of silver nanoparticles were to be discussed using the preferential reaction by the radiolysis.